What is Recurrent Implantation Failure?

  • VFailure to achieve clinical pregnancy after transfer of four good quality embryos in a minimum of three fresh or frozen cycles in a woman under the age of 40 years is known as Recurrent Implantation Failure.
  • It occurs in 10% of women undergoing IVF due to various causes. Implantation is the key event in the establishment of pregnancy.
  • Successful implantation requires interaction between embryo and endometrium.
  • The failure to implant may be secondary to either fault in embryo or endometrium. In two third of cases embryo is at fault and in one third of cases endometrium is at fault.

One needs to be sure about the ovarian stimulation protocols, endometrial thickness and blood flows, no technical difficulty encountered during the embryo transfer and about the laboratory quality control before we label it as Recurrent Implantation Failure. Patient characteristics like oocyte quality and maternal age play key role in determining outcome.